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Last night, after 33 years on TV as a late-night talk show host, David Letterman presented his final program. David Bianculli says Letterman's final show was a strong end to an illustrious career.

In veiled conversations, some doctors may explain to dying patients how to hasten death. But overwhelmed families are left with profound questions and the feeling that no one can answer them.

After launching a quilt company as a desperation move, Jenny Doan and her two savvy kids have shaken up an ancient industry in downtown Hamilton, Mo., thanks in part to popular folksy video tutorials.

NPR's Robert Siegel reports from John Jay College of Criminal Justice in New York on how policing is being taught during this year filled with news of tensions between police and civilians.

Police in Washington responded to a call about a Bengal tiger — turns out it was a stuffed animal. In Thailand, an elephant grabbed a tourist's camera. Instead of a selfie, can we call it an elfie?

Watch two master musicians combine the sounds of harp and guitar into a singular, evocative instrument in music influenced by Africa and Asia.

In polluted Pittsburgh, a new device from a local university helps residents assess indoor air. It's not the only monitor on the market — but is the only one available to borrow from a public library.

Jason Rezaian has been imprisoned in Tehran for nearly 10 months by the Iranian government. He is accused of vaguely-defined espionage charges.

Malaysian authorities discovered graves in several abandoned camps used by human traffickers on the border with Thailand, where Rohingya Muslims fleeing Myanmar were believed to have been held.