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When O'Brien took over for David Letterman on NBC's Late Night, he had virtually no on-air experience. In a 2003 interview, O'Brien tells Fresh Air's Terry Gross about his efforts to fill Letterman's shoes and how his Irish-Catholic repression fuels his comedy.

On Aug. 28, 1963, Lewis was the youngest speaker to address the estimated quarter-million people gathered in Washington. Now a Georgia congressman, he says: "I'm not prepared to sit down and give up."

Yahoo has redesign some of its major sites — the latest step in CEO Marissa Mayer's dramatic turnaround of the Internet company. Before Mayer interviewed for the job at Yahoo, her career at Google appeared to have stalled. Renee Montagne discusses this with Nicholas Carlson, who wrote a profile of Mayer for the news website Business Insider.

When Tropical Storm Irene struck Vermont two years ago, miles of roads were destroyed and 1,400 families were displaced. It didn't take long for the highways to be repaired, but putting people's lives back together has taken much longer. It's been a difficult lesson for a state unaccustomed to natural disasters.

What if Twitter existed 50 years ago, on this monumental anniversary of the March on Washington? Our answer: @TodayIn1963. We've been reporting events of the summer of '63 as if they were happening now, in real-time, through this Twitter account.

The most famous building from the 1970's scandal is the Watergate building in Washington, D.C. A close second has to be the parking garage nearby, where Washington Post reporter Bob Woodward met his source "Deepthroat." But now that historical location is about to become history — it's being torn down and going condo.

Fallon is thankful for slow walkers, people named Lloyd and the word "moist." The comedian and host of Late Night collects more than 100 nuggets of gratitude in a book called Thank You Notes. He talks with Terry Gross about giving thanks and doing impressions.

For Fresh Air's Late Night week, we listen back to a 2008 interview with Seth Meyers, head writer at Saturday Night Live, and the co-anchor of Weekend Update. Meyers will be taking over from Jimmy Fallon on Late Night, now that Fallon is moving to The Tonight Show. A longer version of this interview was originally broadcast on Oct. 29, 2008.

Age-related fumbles of memory are often feared as early signs of Alzheimer's dementia, but recent research confirms an important difference. The underlying biology of the two sorts of memory loss aren't the same. And the age-related form may be reversible someday.

To start with, unlike Moammar Gadhafi's regime when the U.S. intervened in Libya in 2011, the Syrian government still has international allies. As the U.S. considers a strike on Syria, here's a look at some of the key differences between the two situations.